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Journal of Electron Microscopy 47(4): 359-361 (1998)
© 1998 Oxford University Press

Electron microscopic observations and X-ray microanalysis of a multinucleated giant cell

Boon-Huat Bay*,2, Yee-Gek Chan2, Tuck-Yong Yick2 and Hoo-Kwong Leong1,1

1Department of Otorhinolaryngology, National University of Singapore Kent Ridge, Singapore 119260
2Department of Anatomy, National University of Singapore Kent Ridge, Singapore 119260

*To whom correspondence should be addressed: Department of Anatomy, National University of Singapore, Kent Ridge, Singapore 119260. E-mail: antbaybh{at}nus.edu.sg

Giant cells and macrophages play important roles in defence and in reparative functions of the body. This paper describes a giant cell and macrophage present in an inflammatory mass in the temporal bone. X-ray microanalysis performed at the ultrastructural level revealed the presence of a very high iron content in the electron dense precipitates observed in both types of cells. The high iron content is probably due to phagocytosed haemosiderin, a breakdown product of free haemoglobin since there was evidence of haemorrhage present in the biological sections. As the tissue was chemically fixed, it also demonstrates that there is still a place for electron probe microanalysis in tissues (including archived specimens) which have undergone chemical fixation.

Keywords     ultrastructure, macrophage, giant cell, intracellular iron deposits, electron probe microanalysis

Received     19 March 1998, accepted 1 May 1998


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