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Journal of Electron Microscopy 48(1): 39-45 (1999)
© 1999 Oxford University Press

Expression of the neural cell adhesion molecule in mouse taste buds after denervation

Masako Takeda1,*, Yuko Suzuki1, Nobuko Obara1 and Winrich Breipohl2

1Department of Anatomy, School of Dentistry, Health Sciences University of Hokkaido Tobetsu, Ishikari, Hokkaido, 061-02, Japan
2Department of Experimental Ophthalmology, University of Bonn Sigmund Freud Strasse 25, D-53105 Bonn, Germany

*To whom correspondence should be addressed. E-mail: matakeda{at}hoku-iryo-u.ac.jp

Expression of the neural cell adhesion molecule (NCAM) was studied by use of an immunocytochemical technique in the taste buds of mouse circumvallate papillae after bilateral transection of the glossopharyngeal nerves. In untreated mice, innervated type-Ill cells reacted with anti-NCAM antibody. After denervation the taste buds gradually decreased in number and size, and were practically absent within 11 days. In parallel, NCAM-reactive cells decreased at 3 and 8 days after surgery and at 11 days they were no longer found. Three days after denervation, synaptic contacts between type-III cells and nerve fibres were not found because of the disappearance of nerve fibres. However, remaining type-III cells, characterized with dense-cored vesicles, still maintained NCAM expression on their plasma membrane until day 8.

Keywords     taste buds, neural cell adhesion molecule, circumvallate papilla, glossopharyngeal nerve, nerve section, mouse

Received      3 September 1998, accepted 14 September 1998


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