Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ina, K.
Right arrow Articles by Fujikura, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ina, K.
Right arrow Articles by Fujikura, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Electron Microscopy 48(4): 443-448 (1999)
© 1999 Oxford University Press

Ultrastructural and functional changes of the proximal tubular epithelial cells in the renal cortex from spontaneously diabetic KKAy mice

Keisuke Ina*, Hirokazu Kitamura, Kaoruko Nagai, Shuji Tatsukawa and Yoshihisa Fujikura

Department of Anatomy, Oita Medical University Hasama-machi, Oita 879-5593, Japan

*To whom correspondence should be addressed. E-mail: Kina{at}oita-med.ac.jp

To investigate the morphological and functional changes of epithelial cells of proximal tubules in the early stage of diabetic nephropathy, we examined the ultrastructural changes of proximal convoluted tubular cells in spontaneously diabetic KKAy mice.

KKAy mice already showed significant elevation of urinary albumin excretion at 16 weeks of age. Examination revealed that lysosomes were increased in number and conspicuous in the epithelial cells of the proximal convoluted tubules from KKAy mice at 40 weeks of age when compared to control C57BL mice. Furthermore, endogenous IgG was detected in the lysosomes of proximal tubular cells from KKAy mice.

These findings suggested that reabsorption activity was elevated in the proximal tubules of KKAy mice at 40 weeks of age.

Keywords     diabetic nephropathy, diabetic tubulopathy, KKAy mouse, proximal tubule, microvilli, reabsorption

Received     16 July 1998, accepted 13 April 1999


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.