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Journal of Electron Microscopy 51:127-131 (2002)
© 2002 Oxford University Press

Role of matrix metalloproteinase-7 in angiogenesis associated with age-related macular degeneration

Futoshi Yazama 1,3,* , Kazuaki Kadonosono2, Norihiko Itoh2 and Shigeaki Ohno2

1Department of Anatomy and 2Department of Ophthalmology, School of Medicine, Yokohama City University, Kanagawa 236-0004, Japan. Present address (1 April 2002 ~): 3Laboratory of Cell Biology and Morphology, School of Bioresources, Hiroshima Prefectural University, Shoubara-city, Hiroshima 727-0023, Japan

*To whom correspondence should be addressed. E-mail: fyzma{at}med.yokohama-cu.ac.jp

To investigate the possible role of matrix metalloproteinase-7 in choroidal neovascularization associated with age-related macular degeneration, immunoelectron microscopy using ultrathin frozen sections and conventional transmission electron microscopy were performed in subfoveal fibrovascular membranes from patients with age-related macular degeneration. Immunoelectron microscopy revealed that matrix metalloproteinase- 7 was expressed within basal laminar deposits and amorphous materials around the retinal pigment epithelial cells. The results support a role for matrix metalloproteinase-7 in the development of choroidal neovascularization in age-related macular degeneration.

Keywords     ultrathin frozen sections, immunoelectron microscopy, matrix metalloproteinase-7, age-related macular degeneration, choroidal neovascularization, retinal pigment epithelial cells


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