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Journal of Electron Microscopy 52(6): 593-604 (2003)
© Japanese Society of Microscopy

Full-length paper

Expression of extracellular matrix molecules, MMPs and TIMPs in alveolar bone, cementum and periodontal ligaments during rat tooth eruption

Yuriko Maruya1, Yasuyuki Sasano2,*, Ichiro Takahashi3, Manabu Kagayama2 and Hideaki Mayanagi1

1 Division of Pediatric Dentistry, 2 Division of Craniofacial Development and Regeneration and 3 Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan

* To whom correspondence should be addressed. E-mail: sasano{at}anat.dent.tohoku.ac.jp

Abstract

Tooth eruption involves extensive degradation and reorganization of extracellular matrix (ECM) components. It is not known how ECM-degrading enzymes are coordinated with each other or how they are regulated in the event. The present study was designed to investigate mRNA expression of inhibitors of metalloproteinases (TIMPs) in comparison with matrix metalloproteinases (MMPs) as well as ECM molecules during rat first molar eruption using in situ hybridization. We also examined how TIMPs are involved in the process of tooth eruption, root formation, cementogenesis and alveolar bone remodelling. Expressions of type-I collagen, osteocalcin, MMPs 2 and 8, and TIMPs 1, 2 and 3 were shown in osteoblasts, osteocytes, cementoblasts, cementocytes and periodontal ligament fibroblasts, and the concomitant high expressions of the ECM molecules, MMPs and TIMPs in alveolar bone, cementum and periodontal ligaments were identified in the middle of first molar eruption. The remodelling of ECM in these periodontal tissues might be regulated through balance among the production of ECM molecules, the degradation of ECM by MMPs and the inhibition of MMPs by TIMPs during tooth eruption.

Keywords     MMP, TIMP, tooth eruption, bone, cementum, in situ hybridization

Received     30 July 2003, accepted 16 September 2003


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