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Journal of Electron Microscopy 52(6): 615-625 (2003)
© Japanese Society of Microscopy

Full-length paper

Fluoride and apatite formation in vivo and in vitro

Takaaki Aoba1,*, Yoshihito Shimazu1, Yuji Taya1, Yuuichi Soeno1, Kaori Sato1 and Yasuo Miake2

1 Nippon Dental University, Department of Pathology, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8158 and 2 Tokyo Dental College, Oral Health Science Center, Department of Ultrastructural Science, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan

* To whom correspondence should be addressed. E-mail: pathology-ndu{at}tokyo.ndu.ac.jp

Abstract

In recent years, the biomineralization process has attracted much interest from academics and industries for potential technological application. The rule in biomineralization is to have a variety of interfaces and surfaces which can act as nucleators. The ultimate step in any biomineralization process, i.e. the deposition of mineral, must conform to the driving forces operating on the system. A new paradigm in the assessment of the driving force for biomineralization is that a variety of ions existing in the mineralizing milieu are not a bystander, but are instead an active player that directly regulates the precipitation process and nature of biogenic apatites. Thus, the most putative stoichiometric model of a biomineral is (Ca)5-x(Mg)q(Na)u(HPO4)v(CO3)w(PO4)3-y(OH,F)1-z. Fluoride participates in many aspects of calcium phosphate formation in vivo and has enormous effects on its process and on the nature and properties of the final products. In the development of biogenic apatites, fluoride ion in the mineralizing media is supposed to accelerate the hydrolysis of acidic precursor(s) and increase the growth rates by augmenting the driving force for precipitation. Inhibitory activities of ions and molecules are related to their adsorption onto the apatite surfaces. From theoretical and practical points of view, it is of paramount importance to elucidate and predict the effect and outcome of fluoride (accelerator) and inhibitors of biological relevance, because of their use in combination for healthcare in dentistry and medicine, e.g. prevention of dental caries and calculus deposition and in the formulation of antiosteoporosis treatments.

Keywords     biomineralization, fluoride, carbonatoapatite, crystal growth, nucleation and growth

Received     31 July 2003, accepted 16 September 2003


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