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Journal of Electron Microscopy Advance Access published online on June 30, 2009
Journal of Electron Microscopy, doi:10.1093/jmicro/dfp031
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© The Author 2009. Published by Oxford University Press on behalf of Japanese Society of Microscopy. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Ultrastructural megakaryocyte modifications after vanadium inhalation in spleen and bone marrow

Teresa I. Fortoul1,*, Adriana González-Villalva1, Gabriela Piñón-Zarate1, Vianey Rodríguez-Lara1, Luis F. Montaño1 and Liliana Saldivar-Osorio2

1 Department of Cellular and Tissular Biology, School of Medicine and
2 Facultad de Química, National University of Mexico (UNAM), Mexico City, Mexico

* To whom correspondence should be addressed. E-mail: fortoul{at}servidor.unam.mx

Previous reports from our laboratory informed in mice an increase in platelets in blood, and megakaryocytes in spleen and bone marrow after vanadium inhalation. This element has become important in recent years because of its increased presence as an air pollutant. With this precedent, we evaluate the ultrastructural modifications in MKs from the spleen and bone marrow in our mouse experimental model. Mice inhaled 0.02 M V2O5 1 h twice a week for 12 weeks. Tissues were processed for transmission electron microscopy. Results indicate an increase in the size and cytoplasmic granular content, as well as nuclear changes in MKs of exposed mice, changes which correlate with the time of exposure. Modifications in MKs described here suggest that inhaled vanadium induce megakaryocytic maturation, a raise in its granules content and demarcation membrane systems, which may lead to a rise in circulating platelet production and an increased risk for thromboembolic events.

Keywords     megakaryocytosis, vanadium, ultrastructure, transition metals, granules

Received      4 February 2009, accepted 24 May 2009


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