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Journal of Electron Microscopy Advance Access published online on August 27, 2009
Journal of Electron Microscopy, doi:10.1093/jmicro/dfp041
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Morphological changes in the tongue as a consequence of manganese inhalation in a murine experimental model: Light and scanning electron microscopic analysis

Teresa Imelda Fortoul1,*, Madeleine Vélez-Cruz1, Silvia Antuna-Bizarro1, Luis F. Montaño1, Vianey Rodriguez-Lara1 and Liliana Saldivar-Osorio2

1 Cellular and Tisular Department, School of Medicine
2 Facultad de Química, UNAM, Mexico

* To whom correspondence should be addressed. E-mail: fortoul{at}servidor.unam.mx

Air pollution by suspended particles has become a worldwide health problem. The main sources of these particles are fossils and additives combustion. Mn enters the body through inhalation, but part of the particles accesses contact with tongue's posterior surface where lingual tonsils and lingual papillae are placed. We decided to explore in a mouse model, the impact that the deposit of inhaled Mn has on the tongue's surface. Atrophy of the lingual tonsil, filiform papillae, as well as the swelling of taste buds in fungiform papillae, were the predominant changes. Ferropenic anemia is associated with the changes described and could be related to the interference of Mn in iron metabolism and riboflavin absorption. More research should be done to explore the participation of suspended particles trapped in the oral cavity in toxicology of Mn or other inhaled pollutants.

Keywords     manganese, oral cavity, tongue, inhalation exposure, scanning electron microscopy

Received     29 March 2009, accepted 15 July 2009


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