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Journal of Electron Microscopy 32(2): 115-124 (1983)
© 1983 Oxford University Press

Navelbine: An Ultrastructural Study of Its Effects

Michel-Rene PAINTRAND and Isabelle PIGNOT

Hôpital Paul-Brousse, Institut de Cancérologie et d'Immunogénétique(I.N.S.E.R.M. U-50) 94804 Villejuif Cedex, France

An ultrastructural investigation on P388 murine leukemia in viva shows that navelbine, a new semi-synthetic anticancer drug belonging to the group of Vinca alkaloids, induces total depolymerization of microtubules, apparently without causing a concomitant aggregation of intermediate filaments. The accumulation of inclusion bodies, consisting of ribosome clusters and abnormally large tubules, suggests a stimulation of microtubular protein synthesis. In addition, the appearance of intracytoplasmic paired cisternae differentiated from the endoplasmic reticulum seems to be directly related to microtubule depolymerization.

Keywords     navelbine, microtubule paracrystal, mixed inclusion body, intermediate filament

Received     16 May 1982, accepted 2 May 1983


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