Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Fujimoto, T.
Right arrow Articles by Nomura, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fujimoto, T.
Right arrow Articles by Nomura, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Electron Microscopy 47(5): 451-460 (1998)
© 1998 Oxford University Press

Review Caveolae: from a morphological point of view

Toyoshi Fujimoto*, Haruo Hagiwara, Takeo Aoki, Hiroshi Kogo and Ryuji Nomura

Department of Anatomy and Cell Biology, Gunma University School of Medicine Maebashi 371-8511, Japan

*To whom correspondence should be addressed. E-mail: tfujimot{at}sb.gunma-u.ac.jp

Caveolae in the plasma membrane have been a focus of intensive research during the past several years. There has been confusion concerning caveolae and caveola-like membrane domains, but it is now generally thought that the latter is a region distinct from caveolae. However, due to similar buoyancy of caveolae and caveola-like membranes, whether caveolae in situ are enriched with a given molecule is often difficult to be concluded by biochemical techniques alone. Furthermore, relatively shallow caveolae may be detected by some techniques, but not by others. Thus whether a molecule is enriched in caveolae should be confirmed by methods based on different principles. Among many putative caveolar molecules, those related to Ca2+ influx and extrusion were shown to be concentrated in caveolae by both immunocytochemical and biochemical techniques. In conjunction with other characteristics, the result implies that caveolae may function as a mobile compartment for Ca2+ signalling.

Keywords     caveolae, plasma membrane, calcium, immunocytochemistry

Received      9 January 1998, accepted 1 July 1998


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. A. Predescu, D. N. Predescu, and A. B. Malik
Molecular determinants of endothelial transcytosis and their role in endothelial permeability
Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L823 - L842.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Nohe, E. Keating, T. M. Underhill, P. Knaus, and N. O. Petersen
Dynamics and interaction of caveolin-1 isoforms with BMP-receptors
J. Cell Sci., February 1, 2005; 118(3): 643 - 650.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. Nomura, A. Kiyota, E. Suzaki, K. Kataoka, Y. Ohe, K. Miyamoto, T. Senda, and T. Fujimoto
Human Coronavirus 229E Binds to CD13 in Rafts and Enters the Cell through Caveolae
J. Virol., August 15, 2004; 78(16): 8701 - 8708.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Kogo, T. Aiba, and T. Fujimoto
Cell Type-specific Occurrence of Caveolin-1{alpha} and -1{beta} in the Lung Caused by Expression of Distinct mRNAs
J. Biol. Chem., June 11, 2004; 279(24): 25574 - 25581.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
N. B. Chauhan
Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease
J. Lipid Res., November 1, 2003; 44(11): 2019 - 2029.
[Abstract] [Full Text]

Home page
 Mol. Biol. CellHome page
J. Chunqiu Hou and J. E. Pessin
Lipid Raft Targeting of the TC10 Amino Terminal Domain Is Responsible for Disruption of Adipocyte Cortical Actin
Mol. Biol. Cell, September 1, 2003; 14(9): 3578 - 3591.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Kanzaki and J. E. Pessin
Caveolin-associated Filamentous Actin (Cav-actin) Defines a Novel F-actin Structure in Adipocytes
J. Biol. Chem., July 12, 2002; 277(29): 25867 - 25869.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
T. Fujimoto, H. Kogo, K. Ishiguro, K. Tauchi, and R. Nomura
Caveolin-2 Is Targeted to Lipid Droplets, a New "Membrane Domain" in the Cell
J. Cell Biol., March 5, 2001; 152(5): 1079 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
T Fujimoto, H Kogo, R Nomura, and T Une
Isoforms of caveolin-1 and caveolar structure
J. Cell Sci., January 10, 2000; 113(19): 3509 - 3517.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
M. Teubl, K. Groschner, S. D. Kohlwein, B. Mayer, and K. Schmidt
Na+/Ca2+ Exchange Facilitates Ca2+-dependent Activation of Endothelial Nitric-oxide Synthase
J. Biol. Chem., October 8, 1999; 274(41): 29529 - 29535.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
R. Nomura and T. Fujimoto
Tyrosine-phosphorylated Caveolin-1: Immunolocalization and Molecular Characterization
Mol. Biol. Cell, April 1, 1999; 10(4): 975 - 986.
[Abstract] [Full Text]

Home page
 J. Cell Biol.Home page
R. T. Watson, S. Shigematsu, S.-H. Chiang, S. Mora, M. Kanzaki, I. G. Macara, A. R. Saltiel, and J. E. Pessin
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation
J. Cell Biol., August 20, 2001; 154(4): 829 - 840.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.