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Journal of Electron Microscopy 48(4): 465-469 (1999)
© 1999 Oxford University Press

Effects of ovariectomy on bone morphology in maxillae of mature rats

Akira Ishihara1, Takahisa Sasaki2,*, Kazuhiro Debari2, Ryoichi Furuya1, Tadaharu Kawawa1, Nungavaram S. Ramamurthy3 and Lome M. Golub3

1Department of Prosthodontics, School of Dentistry, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
2Department of Anatomy, School of Dentistry, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
3Department of Oral Biology and Pathology, School of Dental Medicine, Health Sciences Center, State University of New York at Stony Brook Stony Brook, NY 11794-8702, USA

*To whom all correspondence should be addressed. E-mail: akira{at}senzoku.showa_u.ac.jp

Postmenopausal oestrogen deficiency results in bone loss (osteoporosis) in humans and experimental animals. The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. At 5 months after ovariectomy of 3-month-old female rats, the mid and distal femurs and maxillae were dissected and processed for quantitative backscattered electron microscopic examinations. Histomorphometric analysis of femurs in OVX rats showed significant loss in metaphyseal trabecular bone areas compared with sham-operated controls; no significant bone loss was observed in the cortical bone areas of mid-diaphyses in OVX rats. Net bone area in the maxillae of OVX rats was similar to that of sham-operated controls. Bone structure of maxillae in OVX rats was also similar to that in controls. Our results suggest that, in this animal model of osteoporosis, prominent bone loss occurs mainly in the bone areas formed by endochondral ossification such as distal femurs, but those areas formed by intramembranous ossification such as mid-femurs and maxillae sustained less effects by OVX.

Keywords     ovariectomy, maxillae, femurs, backscattered electron microscopy, morpho-metry

Received     17 July 1998, accepted 26 May 1999


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